Newtonmore have all but secured a sixth straight Marine Harvest Premiership title after eclipsing Fort William 7-0.
Second-placed Kyles slumped 4-0 away to Camanachd Cup holders Lovat.
Evan Menzies scored five for More as they went six points clear with three to play and a goal advantage of 15.
Oban Camanachd's 3-3 draw against Glenurquhart at Mossfield confirmed relegating for Inveraray, with the fixture doubling as the Mod Cup game, Camanachd prevailing 2-0 on penalties.
At the Eilan, Menzies opened early and made it 2-0 just before half time. Glen MacKintosh got a third just after the restart and Menzies completed his hat-trick immediately after.
Into the final quarter of the game, Menzies got two more in as many minutes before Scott Chisholm finished the job.
Lovat, who had taken just a single point from two league games before and two after their Camanachd Cup final victory over Kyles, welcomed the same team to Balgate and dominated.
Lorn MacKay and Lewis Tawse scored in the first half before Tawse again and Greg Matheson in the second ensured that the slender chance of Lovat being drawn into the relegation play-off evaporated.
Who will meet Kilmallie in that play-off late in November became even less certain after Camanachd's point against Glenurquhart brought them to within three of Kingussie, but with three games in hand.
Neale Reid and Euan Brady put Glen 2-0 up early on and Daniel MacVicar's response was cancelled out by Reid's second. Aiden MacIntyre stepped in as Camanachd's saviour when he scored, then completed a double in the penultimate minute to grab a potentially vital point.
Meanwhile, Inveraray's 4-3 defeat of Kinlochshiel was a case of too little, too late since they are no longer able to catch any other team and will replace Skye in the National Division next season.
Inveraray were 4-1 up after 70 minutes with one each from Euan McMurdo and Gary MacPherson followed by a David Robertson double, with only Keith MacRae replying for Shiel.
The game then sparked into life in the last three minutes when Keith MacRae's second and one from Duncan MacRae made it 4-3, leaving the result delicately poised, albeit briefly.
In addition to Camanachd's Premiership game, Oban also hosted a town derby in South Division 1 between Lochside Rovers, Camanachd's reserve team, and Oban Celtic.
A 5-2 win for leaders Rovers maintained the status quo at the top since Bute, who appear to be enjoying something of a revival, remained two points behind with a game in hand thanks to an 8-0 rout of visitors Glenorchy, with Robert Walker scoring four.