Liz Johnson won the first European Championship medal of her career, as one of four British winners in Berlin.
Paralympic champion Johnson clocked a personal best of one minute 38.89 secs to win the SB6 100m breaststroke from team-mate Charlotte Henshaw.
Thomas Young clinched gold in the SB7 100m breaststroke, while Louise Watkin defended her SM9 200m individual medley title.
And world champion Dan Pepper won the S14 200m freestyle.
Johnson, who clocked a personal best time of one minute 38.89 seconds in the breaststroke, was pushed all the way by defending champion and team-mate, Charlotte Henshaw, who finished in 1min 39.98secs.
"My first European Championships was 10 years ago and this is the first time I have ever been European champion so I am over the moon," said Johnson.
"I did two years of base work after Beijing and I think that has put me in a good position for this season. I have put work in on my speed and my race specific skills and that really came together today."
James Crisp, Emma Hollis and Robert Welbourn set British records on the way to SM9 200m individual medley silver, SB7 100m breaststroke bronze and SM10 200m individual medley bronze respectively.
Heather Frederiksen (S8 50m freestyle) and Natalie Massey (S14 200m freestyle) won silver medals, while there were bronzes for Ben Procter (S14 200m freestyle), Gemma Almond (SM10 200m individual medley) and Claire Cashmore (SM9 200m individual medley).
Young put his disappointment of Sunday's S7 100m backstroke behind him to clinch gold in his event - two years after being disqualified after touching first at the last European Championships.
"I knew coming out from the heats that I would have a good shout for the gold medal," he stated. "I knew I would have to go sub 25 to get the gold.
"I got back and got rested up, had some food and pushed out a 24 which I am really chuffed about."
Watkin's time of 2:35.99 in the individual medley knocked more than a second off the European record.
"It was a tough race from start to finish," she commented. "Obviously I was down after the Fly leg but I pulled it back as hard as I could and thankfully it worked and I got the gold medal.
"When I turned for the last 50, I thought there was no way I would catch up but I pushed hard and managed to overtake her."
And world champion Pepper held off a determined challenge from Dutch swimmer Marc Evers to set a British S14 200m freestyle record of 2:01.27.
"I found that race very hard," said Pepper. "I went out a bit quicker than I normally do which I thought might have affected my back end but luckily I had enough in the last 25 to hold off Marc [Evers]."
"I'm very pleased with the time. I wanted to go a bit quicker if I'm honest but I am not going to complain. A personal best is a personal best and I am delighted."