Double Paralympic champion Eleanor Simmonds beat her own world record in the women's SM6 200m individual medley at the European Championships.
World champion Simmonds clocked three minutes 8.98 seconds, with fellow Briton Natalie Jones second in 3:11.44.
Louise Watkin won her fifth medal of the week, but a season's best in the S9 50m freestyle was only good enough for silver behind Spain's Sarai Gascon.
And Paralympic Champion Robert Welbourn claimed the men's S10 400m freestyle.
Simmonds, who won two golds at the Beijing Games aged 13 to become Britain's youngest individual Paralympic champion, took the lead with a storming freestyle leg and displayed great strength through the final 50m.
"I am really happy to have got the world record in the 400m free and then to top it off with the world record tonight - I am just so happy," said the now 16-year-old, who won the BBC Young Sports Personality of the Year for 2008.
Welbourn went out hard in the final and found himself chased all the way by German Lucas Ludwig.
With 100m to go, Welbourn had opened up a two-second lead over his rival and eventually won by nearly a second, in 4:11.18.
"It certainly was a really tough race," Welbourn said. "I haven't done a 400 that has hurt like that in a while. But I can't complain about the result. I could see Lucas. It was a different race for me.
"Normally I am the one that is just behind but this time I made my mark on the race and tried to keep the lead. But this is what all my training has been geared towards and this is what I targeted and this is the result I wanted."
In the S5 200m individual medley 14-year-old Andrew Mullen won bronze.
Making his international debut in Berlin, he impressed with a well-timed swim to secure a time of 3:33.22.
Natalie Massey took almost a second off her personal best from the heats to win bronze in the women's S14 100m backstroke.
The 20-year old - who also won a silver in the 200m freestyle earlier this week - touched home in 1:11.49 while 16-year old Nicole Lough recorded a personal best of 1:24.25 to finish eighth in her first international final.
National Performance Director John Atkinson said: "I have been pleased with the attitude of the team on what proved to be a tougher night for us. The athletes continued to work hard and pull out outstanding results."