Andy Murray will be joined by fellow Britons Laura Robson and Elena Baltacha in Friday's packed Wimbledon schedule.
Murray plays Ivan Ljubicic for a place in the last 16, third on Centre Court at around 1700 BST.
Robson's rain-delayed second-round match against Maria Sharapova is on Court One at 1300 BST, while British number one Baltacha plays Shuai Peng first on Court 18 at 1200 BST.
Rafael Nadal, Andy Roddick and Venus Williams are also in action on Friday.
Three-time finalist Roddick opens play on Centre at 1300 BST against Spain's Feliciano Lopez, before Victoria Azarenka takes on Daniela Hantuchova, with Murray and Ljubicic to follow.
Robson, the 17-year-old from London, will get her chance to play fifth seed and 2004 champion Maria Sharapova after they failed to make it onto court on Thursday because of repeated rain interruptions.
"You've got to be confident going into these matches, otherwise what's the point of going out there?" said Robson. "I know I can play really well. Just have to wait and see. Hopefully I can play as well as I know I can."
Five-time champion Williams then plays Maria Jose Martinez Sanchez of Spain, before defending champion and world number one Nadal takes on Gilles Muller in the final match on Court One.
Muller, from Luxembourg, was the last man aside from Roger Federer to beat Nadal at Wimbledon back in 2005, when the Spaniard was 19 years old.
The weather forecast is much better for Friday but Murray will enjoy the certainty of knowing his match against Ljubicic will go ahead under the Centre Court roof if necessary.
And Murray believes he will be in for a tough test from the 32-year-old Croatian in their third-round clash, with the pair sharing a 3-3 head-to-head record.
"I've lost to Ljubicic a few times and I expect that to be a difficult match," said Murray.
"He serves well and that always makes it difficult. I need to make sure I can return well, which I did very well at Queen's, and I need to do the same again on Friday."
The 24-year-old Scot did not drop a set as he beat Tobias Kamke in the second round but was not entirely happy with his form.
"There was nothing drastically wrong against Kamke," Murray said in his BBC Sport column. "I served well and moved pretty good, but I just wasn't in the right position for some of the shots and need to use my legs a little bit better."
Ljubicic, who reached round three with a 6-4 6-4 6-2 victory over Ukraine's Sergiy Stakhovsky, beat Murray easily in their last meeting in China in October.
"I am really excited about it," Ljubicic, ranked 33rd, told BBC Radio 5 live. "I hope that I can perform and show what I can do and delight the crowd with great tennis.
"I have played him six times and it is 3-3, so it's pretty even, but this is his home court and it's going to be tough for both of us, no doubt about that.
"Andy is one of the best defensive players in our sport. He is a great returner, has a beautiful backhand and it is really difficult to win points against him as he runs everything down."
And on playing in front of Murray's home crowd, Ljubicic added: "I have played Davis Cup with a really partisan crowd and I am sure the crowd here at Wimbledon is not going to be problematic, and if I play well the crowd will appreciate it."