Stockport's Liam Broady and Cumbrian debutant Daneika Borthwick won their second-round matches on a mixed day for Britain's junior players.
Broady beat Mathias Borgue and in the girls' event Borthwick overcame Czech 15th seed Jesika Maleckova.
Fourth seed Oliver Golding lost to Jason Kubler while fellow Londoner Oliver Hudson, Bolton's George Morgan and Beverley's Kyle Edmund also lost.
Evan Hoyt, Joshua Ward-Hibbert and Francesca Stephenson were also beaten.
Broady, the 15th seed, needed just over an hour to complete a 6-1 6-4 victory against French junior Borgue while Borthwick in straight sets, 6-2 6-3.
Londoner Golding was beaten in straight sets, 7-6 (9-7) 6-2, by Australian Kubler while Nottingham's Ward-Hibbert was beaten 6-2 7-5 by Austrian seventh seed Dominic Thiem.
Edmund, who had pulled off a first-round upset by beating Brazilian 11th seed Joao Pedro Sorgi, suffered a 6-3 6-7 (6-8) 6-4 loss to Belgian Julien Cagnina in a rain-affected match.
Welsh junior Hoyt was unable to build on his debut victory at SW19 losing 7-6 (7-3) 6-2 to Croatian eighth seed Mate Pavic.
Surrey's Stephenson was beaten by Czech Petra Rohanova 6-2 7-5 and Hudson was beaten in three sets by second seed Thiago Moura Monteiro, 6-4 3-6 6-3.
Play in Ruth Seaborne's clash with Risa Ozaki was suspended with the Sutton player level at one set all with her Japanese opponent.
All of Tuesday's junior doubles matches were postponed because of play being heavily disrupted by the wet weather.