Britain's Jocelyn Rae and Colin Fleming made their Wimbledon exit in the third round on Thursday after losing to Jonathan Erlich and Shahar Peer.
Fleming and Rae, Commonwealth Games winners for Scotland last year, dumped out 10th seeds Dick Norman and Lisa Raymond in the second round.
But they rarely troubled the Israeli pair, losing 6-4 7-5 in 79 minutes.
Top seeds Bob and Mike Bryan, aiming for an 11th Grand Slam title, booked a men's doubles semi-finals spot.
The American duo had few problems in easing past Austrian Jurgen Melzer and German Philipp Petzschner, the fifth seeds, 6-3 6-4 6-4 to get within two wins of more silverware.
The Bryan brothers were pushed all the way by Sweden's Simon Aspelin and Australian Paul Hanley in round three in an epic 6-3 4-6 6-7 (5-7) 6-3 16-14 victory.
They will next play the sixth seeds Michael Llodra from France and Serbian Nenad Zimonjic.
Robert Lindstedt and Horia Tecau, seeded eighth, have already secured their passage to the men's doubles final after beating Christopher Kas and Alexander Peya 6-3 7-6 (7-3) 6-2 in their semi-final.