Ireland's Conor Niland will face world number one and top seed Novak Djokovic in the first round of the US Open.
Niland progressed to the main draw of a second successive Grand Slam after beating Dutchman Matwe Middelkoop in the final round of qualifying.
The Limerick man is scheduled to face the Wimbledon champion on one of the show courts on Tuesday.
Another Irishman Louk Sorensen has also qualified and will face Sweden's sixth seed Robin Soderling.
In his final qualifying match on Friday, 199th ranked Niland recovered from losing the opening set to beat world number 258 Middelkoop 2-6 6-1 6-4 in the final qualifying round in New York.
Niland made his first Grand Slam main draw at Wimbledon in June when he lost in five sets to France's Adrian Mannarino.
Sorensen, who has returned to action at the US Open after reversing his decision to retire earlier this year, defeated Austria's Malek Jaziri in straight sets in his final qualifying match on Friday.
The 26-year-old reached the second round of the Australian Open in 2009 but his absence from the circuit in recent months because of injury has resulted in his ranking dropping to a current position of 614.
Niland and Sorensen are the first Irishman to qualify for the US Open since Matt Doyle in the 1980s.