British interest in the main draws at Wimbledon ended after Naomi Broady, Neal Skupski and Jamie Murray all lost in the mixed doubles quarter-finals.
Broady, who reached the second round of the women's singles, and Skupski were beaten by 16th seeds Aisam Qureshi and Vera Dushevina 6-4 6-3 on Court One.
Murray and Australian partner Casey Dellacqua lost 6-2 3-6 6-3 to Max Mirnyi and Hao-Ching Chan on court 17.
Murray, 28, won the mixed doubles title in 2007.
"I'm never disappointed when I lose. It's not the be-all and end-all," Murray told BBC Sport.
"To win mixed doubles you have to put a run of five or six good matches together, and each match is a battle. It can be a bit of a lottery but I enjoy it."
Dellacqua, 29, hopes to continue her partnership with Murray into the US Open, which starts in August.
She said: "I want to play with someone I enjoy playing with, and I've had a good couple of months with Jamie."
British teenager Katie Boulter went out in the quarter-final stage of the girls' doubles.
The 17-year-old from Leicester, alongside partner Ivana Jorovic of Serbia, lost 7-6 (7-5) 5-7 9-7 to the unseeded pairing of American Usue Maitane Arconada and Hungarian Fanny Stollar.
Broady and Skupski, both 24, began their match against Pakistan's Qureshi and Russia's Dushevina strongly, but failed to convert two break points in the opening game before being broken in the next.
The experienced Qureshi, 34, commanded the opening period, hitting some fantastic winners as he and Dushevina saw out a set which included five breaks of serve - taking it when Broady mistakenly left a volley from the Russian.
The Britons rallied in the second but wasted seven opportunities to break Qureshi's serve in the opener, and were again broken at the first time of asking.
The seeds wrapped up victory on their second match point when Broady hit a backhand at the net wide.